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About the Authors

Medetbekova Zh.A. – Neurologist, head of the clinical research laboratory of neurophysiology and audiology, National Center for Children's Rehabilitation, Astana, Kazakhstan

Abdrakhmanova U.Sh. – Head of the emergency room, National Center for Children's Rehabilitation, Astana, Kazakhstan

Zhanibekova S.А. – Dietitian, National Center for Children's Rehabilitation, Astana, Kazakhstan

Muratova N.M. – First-year resident by specialty Neurology, Astana Medical University, Nur-Sultan, Kazakhstan

Sabitova A.K. – First-year resident by specialty Neurology, Astana Medical University, Nur-Sultan, Kazakhstan

Abstract

Epilepsy is one of the most common neurological diseases and is a major problem at any age, which limits a person's capabilities and reduces the quality of life. One of the alternative treatments for epilepsy and epileptic syndromes is the ketogenic diet (KD).

KD is a therapeutic diet with a high fat content, adequate protein and low carbohydrate content. Fats are used as the main source of energy for the body, ketone bodies are produced from fats - hence the name of the diet. An increase in ketone bodies in the blood leads to a decrease in seizures in patients with epilepsy and epileptic syndromes.

Objective: Evaluation of the effectiveness of the ketogenic diet in the treatment of children with epileptic syndromes in various neurological diseases in different age categories.

Materials and Methods: An analysis of the effectiveness of the ketogenic diet was conducted in 30 patients who received rehabilitation treatment at the NCCR aged 2 to 18 years with various neurological diseases for the period 2021-2023.

Results: As a result of the treatment, a positive effect was observed in the majority (65%) of patients, relief of attacks – in 21%, while no dynamics – in 14%.

Keywords

Ketogenic diet, epilepsy, epileptic syndromes, effectiveness.

References

1. Ara Ko, Hye Eun Kwon, Heung Dong Kim. Updates on the ketogenic diet therapy for pediatric epilepsy. Biomedical Journal 2022, Page 19.
2. Widjaja E, Jain P, Demoe L, Guttmann A, Tomlinson G, Sander B. Seizure outcome of pediatric epilepsy surgery: systematic review and meta-analyses. Neurology. 2020;94(7):311–21.
3. Jana Wells, Arun Swaminathan, Jenna Paseka and Corrine Hanson. Efficacy and Safety of a Ketogenic Diet in Children and Adolescents with Refractory Epilepsy—A Review. Nutrients 2020.
4. Elizabeth Neal. Dietary treatment of epilepsy. Practical implementation of ketogenic therapy. 2016. Page 21-22.
5. Michal Fila, Jan Chojnacki, Elzbieta Pawlowska, Piotr Sobczuk, Cezary Chojnacki and Janusz Blasiak. The Ketogenic Diet in the Prevention of Migraines int he Elderly. Nutrients2023, 15, 4998.Page 1-2.
6. Schreck K.C., Hsu F.-C., Berrington A., Henry-Barron B., Vizthum D., Blair L., Kossoff E.H., Easter L., Whitlow C.T., Barker P.B., et al. Feasibility and Biological Activity of a Ketogenic/Intermittent-Fasting Diet in Patients With Glioma. Neurology. 2021;97:e953–e963. doi: 10.1212/WNL.0000000000012386. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
7. Martin-McGill K.J., Marson A.G., Tudur Smith C., Young B., Mills S.J., Cherry M.G., Jenkinson M.D. Ketogenic diets as an adjuvant therapy for glioblastoma (KEATING): A randomized, mixed methods, feasibility study. J. Neurooncol. 2020; 147:213–227. doi: 10.1007/s11060-020-03417-8. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
8. Rusek M., Pluta R., Ułamek-Kozioł M., Czuczwar S.J. Ketogenic diet in alzheimer’s disease. Int. J. Mol. Sci. 2019;20:3892. doi: 10.3390/ijms20163892. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
9. Decampo, D.M.; Kossoff, E.H. Ketogenic dietary therapies for epilepsy and beyond. Curr. Opin. Clin. Nutr. Metab. Care 2019, 22, 264–268. [CrossRef]
10. Nagita Devi, Priyanka Madaan, Nidhun Kandoth, Dipika Bansal, Jitendra Kumar Sahu. Efficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy. JAMA Pediatr. 2023 Jan 30;177(3):258–266.
11. Borowicz-Reutt, K.; Krawczyk, M.; Czernia, J. Ketogenic Diet in the Treatment of Epilepsy. Nutrients 2024, 16, 1258, Page 7-9.
12. Ryan W.Y. Leea,b,c, Michael J. Corleye, Alina Pange, Gaye Arakakif, Lisa Abbottc, Michael Nishimotoa, Rob Miyamotoc, Erica Leee, Susan Yamamotoc, Alika K. Maunakeae, Annette Lum-Jonese, and Miki Wongc. A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder. HHS Public Access,Author manuscript, Physiol Behav 2018.Page 2-3.
13. Cinzia Ferraris, Monica Guglielmetti, Ludovica Pasca, Valentina De Giorgis. Impact of the Ketogenic Diet on Linear Growth in Children: A Single-Center Retrospective Analysis of 34 Cases. Nutrients 2019. Page 1-2.