87085036573
CALL center
87172511555, 87172511612
Registry
Turan Avenue, 36
Astana city

Aspects of rehabilitation of patients with spinal muscular atrophy

Article PDF


About the Authors

Nasihat TulekovaChairman of the Board of JSC "CRC Balbulak", This email address is being protected from spambots. You need JavaScript enabled to view it.

Gulnar MukhambetovaProfessor of the Department of Nervous Diseases of the S.D. Asfendiyarov Kazakh National Medical University, This email address is being protected from spambots. You need JavaScript enabled to view it., https://orcid.org/0000-0002-2673-4171

Nesibeli MoldazharovaDeputy Chairman of the Board for MRW of JSC "CRC Balbulak"

Marjan OxikbayResidency student in the specialty "Neurology, adult, pediatric" of the Department of Nervous Diseases of the Kazakh National Medical University named after S.D. Asfendiyarov, This email address is being protected from spambots. You need JavaScript enabled to view it., https://orcid.org/0009-0008-7094-5962

Bakhyt MukhambetovaResidency student in the specialty "Neurology, adult, pediatric" of the Department of Nervous Diseases of the Kazakh National Medical University named after S.D. Asfendiyarov, This email address is being protected from spambots. You need JavaScript enabled to view it., https://orcid.org/0009-0000-2196-5571

Madina AskerbekovaResidency student in the specialty "Neurology, adult, pediatric" of the Department of Nervous Diseases of the Kazakh National Medical University named after S.D. Asfendiyarov, This email address is being protected from spambots. You need JavaScript enabled to view it., https://orcid.org/0009-0004-4249-4763

Aruzhan KenesbekResidency student in the specialty "Neurology, adult, pediatric" of the Department of Nervous Diseases of the Kazakh National Medical University named after S.D. Asfendiyarov, This email address is being protected from spambots. You need JavaScript enabled to view it., https://orcid.org/0009-0008-6052-5198


Abstract

The аrticle presents an аnalysis of scientific evidence of the effectiveness of modern rehabilitation technologies in patients with spinal muscular atrophy. The key areas of rehаbilitation are considered, including physiotherapy, respiratory support, orthopedic correction, occupational therapy and methods of improving functional independence. Bаsed on the analysis of recent publications, their impact on physical activity, prevention of complications and quality of life of patients is assessed. Special attention is paid to the role of a multidisciplinary approach and the interаction of rehabilitation with innovative drug therapy. The findings emphasize the need to integrate evidence-based rehаbilitation techniques into the comprehensive manаgement of patients with spinаl muscular atrophy.


Key words

Spinal muscular atrophy, rehabilitation.


References

  1. Foead, A. I. (2019). Rehabilitation in spinal muscular atrophy. The Journal of the International Society of Physical and Rehabilitation Medicine, 2(1), 62–70.
    https://journals.lww.com/jisprm/fulltext/2019/02010/rehabilitation_in_spinal_muscular_atrophy.11.aspx
  2. Пономаренко, Г. Н., Мальцев, И. С., Кольцов, А. А., Черкашина, И. В. (2023). Медицинская реабилитация пациентов со спинальной мышечной атрофией. Вопросы курортологии, физиотерапии и лечебной физической культуры, 100(2), 5–13. https://elibrary.ru/item.asp?id=52510130

Ponomarenko, G. N., Maltsev, I. S., Koltsov, A. A., & Cherkashina, I. V. (2023). Meditsinskaya reabilitatsiya patsientov so spinal'noy myshechnoy atrofiyey (Medical rehabilitation of patients with spinal muscular atrophy) [in Russian]. Voprosy kurortologii, fizioterapii i lechebnoy fizicheskoy kul'tury, 100(2), 5–13. https://elibrary.ru/item.asp?id=52510130

  1. Айрапетян, Э. Н. (2021). Спинальная мышечная атрофия. Здоровье нации в XXI веке, №2, 122–125. https://cyberleninka.ru/article/n/spinalnaya-myshechnaya-atrofiya

Airapetyan, E. N. (2021). Spinal'naya myshechnaya atrofiya (Spinal muscular atrophy) [in Russian]. Zdorov'e natsii v XXI veke, (2), 122–125. https://cyberleninka.ru/article/n/spinalnaya-myshechnaya-atrofiya

  1. Bartels, B., Montes, J., van der Pol, W. L., & de Groot, J. F. (2019). Physical exercise training for type 3 spinal muscular atrophy. Cochrane Database of Systematic Reviews, 3(3), CD012120. https://pubmed.ncbi.nlm.nih.gov/30821348/
  2. Mergen Kilic, S., Mutluay, F., Cakar, A., Giris, M., Durmus, H., Bingul, I., Gedikbasi, A., Kucukgergin, C., Uyguner, Z. O., & Parman, Y. (2025). The effect of aerobic exercise training on patients with type III spinal muscular atrophy. Journal of Clinical Medicine,14(17), Article 6087. https://doi.org/10.3390/jcm14176087
  3. Prat-Ortega, G., Ensel, S., Donadio, S., Borda, L., Boos, A., Yadav, P., Verma, N., Ho, J., Carranza, E., Frazier-Kim, S., Fields, D. P., Fisher, L. E., Weber, D. J., Balzer, J., Duong, T., Weinstein, S. D., Eliasson, M. J. L., Montes, J., Chen, K. S., Clemens, P. R., Gerszten, P., Mentis, G. Z., & Capogrosso, M. (2025). First-in-human study of epidural spinal cord stimulation in individuals with spinal muscular atrophy. Nature Medicine, 31(4), 1246–1256. https://doi.org/10.1038/s41591-024-03484-8
  4. Novikov, A., Maldova, M., Shamantseva, N., Shalmiev, I., Shoshina, E., Epoyan, N., Krutikova, N., & Moshonkina, T. (2024). Non-invasive spinal cord stimulation for motor rehabilitation of patients with spinal muscular atrophy treated with orphan drugs. Biomedicines, 12(6), 1162. https://doi.org/10.3390/biomedicines12061162
  5. Zhou, K., Wei, W., Yang, D., Zhang, H., Yang, W., Zhang, Y., Nie, Y., Hao, M., Wang, P., Ruan, H., Zhang, T., Wang, S., & Liu, Y. (2024). Dual electrical stimulation at spinal-muscular interface reconstructs spinal sensorimotor circuits after spinal cord injury. Nature Communications, 15, Article 619. https://doi.org/10.1038/s41467-024-44898-9
  6. Cumplido-Trasmonte, C., Ramos-Rojas, J., Delgado-Castillejo, E., Garcés-Castellote, E., Puyuelo-Quintana, G., Destarac-Eguizabal, M. A., Barquín-Santos, E., Plaza-Flores, A., Hernández-Melero, M., & Gutiérrez-Ayala, A. (2022). Effects of ATLAS 2030 gait exoskeleton on strength and range of motion in children with spinal muscular atrophy II: a case series. Journal of NeuroEngineering and Rehabilitation, 19, Article 75. https://doi.org/10.1186/s12984-022-01055-x
  7. Cumplido Trasmonte, C., Ramos-Rojas, J., Delgado-Castillejo, E., Garcés-Castellote, E., Destarac-Eguizabal, M. A., Puyuelo-Quintana, G., Barquín-Santos, E., Plaza-Flores, A., & Hernández-Melero, M. (2021). Gait-assisted exoskeletons for children with cerebral palsy or spinal muscular atrophy: a systematic review. Neurorehabilitation, 49(4), 1–16. https://pubmed.ncbi.nlm.nih.gov/34219676/
  8. Plaza, A., Gutiérrez, A., Barquín-Santos, E., & Hernández-Melero, M. (2020). Wearable rehabilitation exoskeletons of the lower limb: analysis of versatility and adaptability. Journal of Robotics and Automation,. 18(4):392-406. https://pubmed.ncbi.nlm.nih.gov/33332159/
  9. Song, W., & Ke, X. (2025). Rehabilitation management for patients with spinal muscular atrophy: a review. Orphanet Journal of Rare Diseases, 20, Article 352. https://doi.org/10.1186/s13023-025-03888-w
  10. Moultrie, F., Chiverton, L., Hatami, I., Lilien, C., & Servais, L. (2025). Pushing the boundaries: future directions in the management of spinal muscular atrophy.,Trends in Molecular medicine. 31(4), 307–318. https://pubmed.ncbi.nlm.nih.gov/39794178/

 

200.png
© Copyright 2026 DESIGN BY SITE-PRO.KZ. All Rights Reserved.
Whatsapp Instagram YouTube Запись на консультацию